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A Pit-1 Threonine 220 Phosphomimic Reduces Binding to Monomeric DNA Sites to Inhibit Ras and Estrogen Stimulation of the Prolactin Gene Promoter
Pit-1 is a POU-homeodomain transcription factor that dictates the ontogeny of pituitary somatotrophs, lactotrophs, and thyrotrophs through regulation of their respective protein hormone genes: GH, prolactin (PRL), and TSHβ. Although Pit-1 threonine 220 (T220) and serine 115 are protein kinase phosph...
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| Главные авторы: | , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
The Endocrine Society
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2802898/ https://ncbi.nlm.nih.gov/pubmed/19887646 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2009-0279 |
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