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A Pit-1 Threonine 220 Phosphomimic Reduces Binding to Monomeric DNA Sites to Inhibit Ras and Estrogen Stimulation of the Prolactin Gene Promoter

Pit-1 is a POU-homeodomain transcription factor that dictates the ontogeny of pituitary somatotrophs, lactotrophs, and thyrotrophs through regulation of their respective protein hormone genes: GH, prolactin (PRL), and TSHβ. Although Pit-1 threonine 220 (T220) and serine 115 are protein kinase phosph...

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Bibliografske podrobnosti
Main Authors: Jean, Annie, Gutierrez-Hartmann, Arthur, Duval, Dawn L.
Format: Artigo
Jezik:Inglês
Izdano: The Endocrine Society 2010
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2802898/
https://ncbi.nlm.nih.gov/pubmed/19887646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2009-0279
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