Inter-Monomer Interactions are Essential for Lysosomal Enzyme Binding by the Cation-dependent Mannose 6-Phosphate Receptor

The 46 kDa cation-dependent MPR (CD-MPR) plays a key role in the delivery of lysosomal enzymes to the lysosome by binding newly synthesized mannose 6-phosphate (Man-6-P)-containing acid hydrolases and diverting them from the secretory pathway. Previous studies on a truncated form of the receptor com...

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Bibliographic Details
Main Authors: Olson, Linda J., Sun, Guangjie, Bohnsack, Richard N., Peterson, Francis C., Dahms, Nancy M., Kim, Jung-Ja P.
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2802658/
https://ncbi.nlm.nih.gov/pubmed/19928875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi901725x
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