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Ribonucleases as Novel Chemotherapeutics: The Ranpirnase Example

Ranpirnase (Onconase®), a cytotoxic ribonuclease from the frog Rana pipiens, is the archetype of a novel class of cancer chemotherapeutic agents that are based on homologues and variants of bovine pancreatic ribonuclease (RNase A). Ranpirnase in combination with doxorubicin is in clinical trials for...

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Detalhes bibliográficos
Main Authors: Lee, J. Eugene, Raines, Ronald T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2802594/
https://ncbi.nlm.nih.gov/pubmed/18215091
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