Corticotropin-Releasing Factor (CRF) Sensitization of Ethanol Withdrawal-Induced Anxiety-Like Behavior is Brain Site Specific and Mediated by CRF-1 Receptors: Relation to Stress-Induced Sensitization

In abstinent alcoholics, stress induces negative affect—a response linked to craving and relapse. In rats, repeated stresses at weekly intervals before 5-day ethanol diet sensitize withdrawal-induced anxiety-like behavior (“anxiety”) that is blocked by a corticotrophin-releasing factor 1 (CRF-1)-rec...

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Detalhes bibliográficos
Main Authors: Huang, Mae M., Overstreet, David H., Knapp, Darin J., Angel, Robert, Wills, Tiffany A., Navarro, Montserrat, Rivier, Jean, Vale, Wylie, Breese, George R.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2010
Assuntos:
Neuropharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2802475/
https://ncbi.nlm.nih.gov/pubmed/19843974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.109.159186
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