Regional Differential Effects of the Novel Histamine H(3) Receptor Antagonist 6-[(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]-N-methyl-3-pyridinecarboxamide hydrochloride (GSK189254) on Histamine Release in the Central Nervous System of Freely Moving Rats

After oral administration, the nonimidazole histamine H(3) receptor antagonist, 6-[(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]-N-methyl-3-pyridinecarboxamide hydrochloride (GSK189254), increased histamine release from the tuberomammillary nucleus, where all histaminergic somata are lo...

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Detalhes bibliográficos
Main Authors: Giannoni, Patrizia, Medhurst, Andrew D., Passani, Maria Beatrice, Giovannini, Maria Grazia, Ballini, Chiara, Corte, Laura Della, Blandina, Patrizio
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2010
Assuntos:
Neuropharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2802467/
https://ncbi.nlm.nih.gov/pubmed/19815811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.109.158444
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