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Analysis of genetic variability and mapping of point mutations in influenza virus by the RNase A mismatch cleavage method.

We have applied the RNase A mismatch cleavage method to analyze genetic variability in RNA viruses by using influenza virus as a model system. Uniformly labeled RNA probes synthesized from a cloned hemagglutinin gene of a given viral strain were hybridized to RNA isolated from other strains of chara...

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Publicado no:Proc Natl Acad Sci U S A
Principais autores: Lopez-Galindez, C, Lopez, J A, Melero, J A, de la Fuente, L, Martinez, C, Ortin, J, Perucho, M
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1988
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC280244/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3368463/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.10.3522
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