Spectrum of spontaneous mutation at the APRT locus of Chinese hamster ovary cells: an analysis at the DNA sequence level.

The spectrum of spontaneous mutation of an endogenous mammalian cell gene has been determined at the DNA sequence level. Thirty independent spontaneous APRT- mutations were cloned and subsequently completely sequenced. Twenty-seven contained single base substitutions. Of these, 22 were G.C to A.T tr...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: de Jong, P J, Grosovsky, A J, Glickman, B W
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1988
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC280239/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3368459/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.10.3499
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