Orexin/Hypocretin and Histamine: Distinct Roles in the Control of Wakefulness Demonstrated Using Knock-Out Mouse Models

To determine the respective role played by orexin/hypocretin and histamine (HA) neurons in maintaining wakefulness (W), we characterized the behavioral and sleep–wake phenotypes of orexin (Ox) knock-out (−/−) mice and compared them with those of histidine-decarboxylase (HDC, HA-synthesizing enzyme)−...

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Main Authors: Anaclet, Christelle, Parmentier, Régis, Ouk, Koliane, Guidon, Gérard, Buda, Colette, Sastre, Jean-Pierre, Akaoka, Hidéo, Sergeeva, Olga A., Yanagisawa, Masashi, Ohtsu, Hiroshi, Franco, Patricia, Haas, Helmut L., Lin, Jian-Sheng
Format: Artigo
Jezik:Inglês
Izdano: Society for Neuroscience 2009
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Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2802289/
https://ncbi.nlm.nih.gov/pubmed/19923277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2604-09.2009
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