Na(+) channel regulation by Ca(2+)/calmodulin and Ca(2+)/calmodulin-dependent protein kinase II in guinea-pig ventricular myocytes(†)

AIMS: Calmodulin (CaM) regulates Na(+) channel gating through binding to an IQ-like motif in the C-terminus. Ca(2+)/CaM-dependent protein kinase II (CaMKII) regulates Ca(2+) handling, and chronic overactivity of CaMKII is associated with left ventricular hypertrophy and dysfunction and lethal arrhyt...

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Autores principales: Aiba, Takeshi, Hesketh, Geoffrey G., Liu, Ting, Carlisle, Rachael, Villa-Abrille, Maria Celeste, O'Rourke, Brian, Akar, Fadi G., Tomaselli, Gordon F.
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2010
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Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2802203/
https://ncbi.nlm.nih.gov/pubmed/19797425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvp324
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