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Sorting of Drosophila small silencing RNAs partitions microRNA* strands into the RNA interference pathway

In flies, small silencing RNAs are sorted between Argonaute1 (Ago1), the central protein component of the microRNA (miRNA) pathway, and Argonaute2 (Ago2), which mediates RNA interference. Extensive double-stranded character—as is found in small interfering RNAs (siRNAs)—directs duplexes into Ago2, w...

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Detalhes bibliográficos
Main Authors: Ghildiyal, Megha, Xu, Jia, Seitz, Hervé, Weng, Zhiping, Zamore, Phillip D.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2802036/
https://ncbi.nlm.nih.gov/pubmed/19917635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.1972910
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