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Structural Identification of Diindole Agonists of the Aryl Hydrocarbon Receptor Derived from Degradation of Indole-3-pyruvic Acid

Aerobic incubation of the tryptophan transamination/oxidation product indole-3-pyruvic acid (I3P) at pH 7.4 and 37 °C yielded products with activity as Ah receptor (AHR) agonists. The extracts were fractionated using HPLC and screened for AHR agonist activity. Two compounds were identified as agonis...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Chowdhury, Goutam, Dostalek, Miroslav, Hsu, Erin L., Nguyen, Linh P., Stec, Donald F., Bradfield, Christopher A., Guengerich, F. Peter
פורמט: Artigo
שפה:Inglês
יצא לאור: 2009
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2801742/
https://ncbi.nlm.nih.gov/pubmed/19860413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx9000418
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