Na(+)/H(+) Exchanger Regulatory Factor 1 Overexpression-dependent Increase of Cytoskeleton Organization Is Fundamental in the Rescue of F508del Cystic Fibrosis Transmembrane Conductance Regulator in Human Airway CFBE41o- Cells

We have demonstrated that Na(+)/H(+) exchanger regulatory factor 1 (NHERF1) overexpression in CFBE41o- cells induces a significant redistribution of F508del cystic fibrosis transmembrane conductance regulator (CFTR) from the cytoplasm to the apical membrane and rescues CFTR-dependent chloride secret...

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Autors principals: Favia, Maria, Guerra, Lorenzo, Fanelli, Teresa, Cardone, Rosa Angela, Monterisi, Stefania, Di Sole, Francesca, Castellani, Stefano, Chen, Mingmin, Seidler, Ursula, Reshkin, Stephan Joel, Conese, Massimo, Casavola, Valeria
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Cell Biology 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2801722/
https://ncbi.nlm.nih.gov/pubmed/19889841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E09-03-0185
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