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Localization of a factor VIII-inhibiting antibody epitope to a region between residues 338 and 362 of factor VIII heavy chain.

We have used a recombinant DNA epitope library to localize the binding region of a factor VIII (FVIII) monoclonal antibody that neutralizes coagulant activity. The antibody, C5, has previously been described and has been shown to have a FVIII neutralizing potency of 1488 Bethesda units per mg of pur...

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Publicado en:Proc Natl Acad Sci U S A
Autores principales: Ware, J, Toomey, J R, Stafford, D W
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 1988
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Acceso en línea:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC280164/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2452445/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.9.3165
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