Fragment-based discovery of selective inhibitors of the Mycobacterium tuberculosis protein tyrosine phosphatase PtpA

The development of low μM inhibitors of the Mycobacterium tuberculosis phosphatase PtpA is reported. The most potent of these inhibitors (K(i) = 1.4 ± 0.3 μM) was found to be selective when tested against a panel of human tyrosine and dual-specificity phosphatases (11-fold vs the highly homologous H...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Rawls, Katherine A., Lang, P. Therese, Takeuchi, Jun, Imamura, Shinichi, Baguley, Tyler D., Grundner, Christoph, Alber, Tom, Ellman, Jonathan A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2801607/
https://ncbi.nlm.nih.gov/pubmed/19889539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.10.090
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky