Pretreatment with Pancaspase Inhibitor (Z-VAD-FMK) Delays but Does Not Prevent Intraperitoneal Heat-Killed Group B Streptococcus-Induced Preterm Delivery in a Pregnant Mouse Model

Caspases and apoptosis are thought to play a role in infection-associated preterm-delivery. We have shown that in vitro treatment with pancaspase inhibitor Z-VAD-FMK protects trophoblasts from microbial antigen-induced apoptosis. Objective. To examine whether in vivo administration of Z-VAD-FMK woul...

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Main Authors: Equils, Ozlem, Moffatt-Blue, Chantelle, Ishikawa, Tomo-o, Simmons, Charles F., Ilievski, Vladimir, Hirsch, Emmet
Formato: Artigo
Idioma:Inglês
Publicado: Hindawi Publishing Corporation 2009
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2801448/
https://ncbi.nlm.nih.gov/pubmed/20069051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2009/749432
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