Hypoxic Repression of Endothelial Nitric-oxide Synthase Transcription Is Coupled with Eviction of Promoter Histones

Hypoxia elicits endothelial dysfunction, in part, through reduced expression of endothelial nitric-oxide synthase (eNOS). Here we present evidence that hypoxia causes a rapid decrease in the transcription of the eNOS/NOS3 gene, accompanied by decreased acetylation and lysine 4 (histone H3) methylati...

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Autores principales: Fish, Jason E., Yan, Matthew S., Matouk, Charles C., St. Bernard, Rosanne, Ho, J. J. David, Gavryushova, Anna, Srivastava, Deepak, Marsden, Philip A.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2010
Materias:
Transcription, Chromatin, and Epigenetics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2801283/
https://ncbi.nlm.nih.gov/pubmed/19880524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.067868
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