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Mode of Binding of the Tuberculosis Prodrug Isoniazid to Heme Peroxidases: BINDING STUDIES AND CRYSTAL STRUCTURE OF BOVINE LACTOPEROXIDASE WITH ISONIAZID AT 2.7 Å RESOLUTION

Isoniazid (INH) is an anti-tuberculosis prodrug that is activated by mammalian lactoperoxidase and Mycobacterium tuberculosis catalase peroxidase (MtCP). We report here binding studies, an enzyme assay involving INH, and the crystal structure of the complex of bovine lactoperoxidase (LPO) with INH t...

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Main Authors: Singh, Amit K., Kumar, Ramasamy P., Pandey, Nisha, Singh, Nagendra, Sinha, Mau, Bhushan, Asha, Kaur, Punit, Sharma, Sujata, Singh, Tej P.
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2010
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2801281/
https://ncbi.nlm.nih.gov/pubmed/19907057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.060327
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