Structural Evidence of Substrate Specificity in Mammalian Peroxidases: STRUCTURE OF THE THIOCYANATE COMPLEX WITH LACTOPEROXIDASE AND ITS INTERACTIONS AT 2.4 Å RESOLUTION

The crystal structure of the complex of lactoperoxidase (LPO) with its physiological substrate thiocyanate (SCN(–)) has been determined at 2.4Å resolution. It revealed that the SCN(–) ion is bound to LPO in the distal heme cavity. The observed orientation of the SCN(–) ion shows that the sulfur atom...

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Detalhes bibliográficos
Principais autores: Sheikh, Ishfaq Ahmed, Singh, Amit Kumar, Singh, Nagendra, Sinha, Mau, Singh, S. Baskar, Bhushan, Asha, Kaur, Punit, Srinivasan, Alagiri, Sharma, Sujata, Singh, Tej P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Enzyme Catalysis and Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2685666/
https://ncbi.nlm.nih.gov/pubmed/19339248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M807644200
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