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Structural Evidence of Substrate Specificity in Mammalian Peroxidases: STRUCTURE OF THE THIOCYANATE COMPLEX WITH LACTOPEROXIDASE AND ITS INTERACTIONS AT 2.4 Å RESOLUTION

The crystal structure of the complex of lactoperoxidase (LPO) with its physiological substrate thiocyanate (SCN(–)) has been determined at 2.4Å resolution. It revealed that the SCN(–) ion is bound to LPO in the distal heme cavity. The observed orientation of the SCN(–) ion shows that the sulfur atom...

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Bibliografski detalji
Glavni autori: Sheikh, Ishfaq Ahmed, Singh, Amit Kumar, Singh, Nagendra, Sinha, Mau, Singh, S. Baskar, Bhushan, Asha, Kaur, Punit, Srinivasan, Alagiri, Sharma, Sujata, Singh, Tej P.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2009
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2685666/
https://ncbi.nlm.nih.gov/pubmed/19339248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M807644200
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