Dimeric Coiled-coil Structure of Saccharomyces cerevisiae Atg16 and Its Functional Significance in Autophagy

Atg16 interacts with the Atg12-Atg5 protein conjugate through its N-terminal domain and self-assembles through its coiled-coil domain (CCD). Formation of the Atg12-Atg5·Atg16 complex is essential for autophagy, the bulk degradation process conserved among most eukaryotes. Here, we report the crystal...

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Bibliographic Details
Main Authors: Fujioka, Yuko, Noda, Nobuo N., Nakatogawa, Hitoshi, Ohsumi, Yoshinori, Inagaki, Fuyuhiko
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
Protein Structure and Folding
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2801276/
https://ncbi.nlm.nih.gov/pubmed/19889643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.053520
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