Ku and DNA-dependent Protein Kinase Dynamic Conformations and Assembly Regulate DNA Binding and the Initial Non-homologous End Joining Complex

DNA double strand break (DSB) repair by non-homologous end joining (NHEJ) is initiated by DSB detection by Ku70/80 (Ku) and DNA-dependent protein kinase catalytic subunit (DNA-PKcs) recruitment, which promotes pathway progression through poorly defined mechanisms. Here, Ku and DNA-PKcs solution stru...

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Main Authors: Hammel, Michal, Yu, Yaping, Mahaney, Brandi L., Cai, Brandon, Ye, Ruiqiong, Phipps, Barry M., Rambo, Robert P., Hura, Greg L., Pelikan, Martin, So, Sairei, Abolfath, Ramin M., Chen, David J., Lees-Miller, Susan P., Tainer, John A.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2010
Teme:
DNA: Replication, Repair, Recombination, and Chromosome Dynamics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2801267/
https://ncbi.nlm.nih.gov/pubmed/19893054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.065615
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