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Proline Is Not Uniquely Capable of Providing the Pivot Point for Domain Swapping in 2G12, a Broadly Neutralizing Antibody against HIV-1

The human monoclonal antibody 2G12 is a member of a small group of broadly neutralizing antibodies against human immunodeficiency virus type 1. 2G12 adopts a unique variable heavy domain-exchanged dimeric configuration that results in an extensive multivalent binding surface and the ability to bind...

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Bibliografiske detaljer
Main Authors: Gach, Johannes S., Furtmüller, Paul G., Quendler, Heribert, Messner, Paul, Wagner, Ralf, Katinger, Hermann, Kunert, Renate
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2801240/
https://ncbi.nlm.nih.gov/pubmed/19903812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.058792
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