A Human Antibody to the CD4 Binding Site of gp120 Capable of Highly Potent but Sporadic Cross Clade Neutralization of Primary HIV-1

Primary isolates of HIV-1 resist neutralization by most antibodies to the CD4 binding site (CD4bs) on gp120 due to occlusion of this site on the trimeric spike. We describe 1F7, a human CD4bs monoclonal antibody that was found to be exceptionally potent against the HIV-1 primary isolate JR-FL. Howev...

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Main Authors: Gach, Johannes S., Quendler, Heribert, Tong, Tommy, Narayan, Kristin M., Du, Sean X., Whalen, Robert G., Binley, James M., Forthal, Donald N., Poignard, Pascal, Zwick, Michael B.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3753353/
https://ncbi.nlm.nih.gov/pubmed/23991039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0072054
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