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The drusen-like phenotype in aging Ccl2 knockout mice is caused by an accelerated accumulation of swollen autofluorescent subretinal macrophages
PURPOSE: Drusen, which can be defined clinically as yellowish white spots in the outer retina, are cardinal features of age-related macular degeneration (AMD). Ccl2 knockout (Ccl2(-/-)) mice have been reported to develop drusen and phenotypic features similar to AMD including an increased susceptibi...
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| Главные авторы: | , , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2009
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2801148/ https://ncbi.nlm.nih.gov/pubmed/19578022 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.09-3462 |
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