In Vivo Therapeutic Silencing of Hypoxia-Inducible Factor 1 Alpha (HIF-1α) Using Single-Walled Carbon Nanotubes Noncovalently Coated with siRNA

A new approach is described for delivering small interfering RNA (siRNA) into cancer cells by noncovalently complexing unmodified siRNA with pristine single-walled carbon nanotubes (SWCNTs). The complexes were prepared by simple sonication of pristine SWCNTs in a solution of siRNA, which then served...

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Bibliografiske detaljer
Main Authors: Bartholomeusz, Geoffrey, Cherukuri, Paul, Kingston, John, Cognet, Laurent, Lemos, Robert, Leeuw, Tonya K., Gumbiner-Russo, Laura, Weisman, R. Bruce, Powis, Garth
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2801079/
https://ncbi.nlm.nih.gov/pubmed/20052401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12274-009-9026-7
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