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Switching from an induced fit to a lock and key mechanism in an aminoacyl-tRNA synthetase with modified specificity
Methionyl-tRNA synthetase (MetRS) specifically binds its methionine substrate in an induced fit mechanism, with methionine binding causing large rearrangements. Mutated MetRS able to efficiently aminoacylate the methionine (Met) analog azidonorleucine (Anl) have been identified by saturation mutagen...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2009
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2801061/ https://ncbi.nlm.nih.gov/pubmed/19837083 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2009.10.016 |
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