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SylC Catalyzes Ureido-Bond Formation During Biosynthesis of the Proteasome Inhibitor Syringolin A

[Image: see text] Syringolins are a class of cyclic tripeptide natural products that are potent and irreversible inhibitors of the eukaryotic proteasome. In addition to being hybrid NRPS/PKS molecules, they also feature an unusual ureido-linkage (red) between two amino acid monomers. Here we report...

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Bibliografske podrobnosti
Main Authors: Imker, Heidi J., Walsh, Christopher T., Wuest, William M.
Format: Artigo
Jezik:Inglês
Izdano: 2009
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2800832/
https://ncbi.nlm.nih.gov/pubmed/19968303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja909170u
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