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Activated Protein C is Neuroprotective and Mediates New Blood Vessel Formation and Neurogenesis After Controlled Cortical Impact

OBJECTIVE: Activated protein C (APC) is neuroprotective in stroke models and promotes post-ischemic neovascularization and neurogenesis. We utilized a controlled cortical impact (CCI) in mice to determine APC's effects on neuroprotection and angiogenesis and neurogenesis following traumatic bra...

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Bibliographische Detailangaben
Hauptverfasser: Petraglia, Anthony L., Marky, Andrew H., Walker, Corey, Thiyagarajan, Meenakshisundaram, Zlokovic, Berislav V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2800370/
https://ncbi.nlm.nih.gov/pubmed/20023547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1227/01.NEU.0000363148.49779.68
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