Failure of Interferon γ to Induce the Anti-Inflammatory Interleukin 18 Binding Protein in Familial Hemophagocytosis

BACKGROUND: Familial hemophagocytosis (FHL) is a rare disease associated with defects in proteins involved in CD8(+) T-cell cytotoxicity. Hyperactivation of immune cells results in a perilous, Th1-driven cytokine storm. We set out to explore the regulation of cytokines in an FHL patient who was clin...

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Bibliografiske detaljer
Main Authors: Nold-Petry, Claudia A., Lehrnbecher, Thomas, Jarisch, Andrea, Schwabe, Dirk, Pfeilschifter, Josef M., Muhl, Heiko, Nold, Marcel F.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2010
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2800185/
https://ncbi.nlm.nih.gov/pubmed/20072626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0008663
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