Nearby inverted repeats fuse to generate acentric and dicentric palindromic chromosomes by a replication template exchange mechanism

Gene amplification plays important roles in the progression of cancer and contributes to acquired drug resistance during treatment. Amplification can initiate via dicentric palindromic chromosome production and subsequent breakage–fusion–bridge cycles. Here we show that, in fission yeast, acentric a...

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Библиографические подробности
Главные авторы: Mizuno, Ken'Ichi, Lambert, Sarah, Baldacci, Giuseppe, Murray, Johanne M., Carr, Antony M.
Формат: Artigo
Язык:Inglês
Опубликовано: Cold Spring Harbor Laboratory Press 2009
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Research Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2800087/
https://ncbi.nlm.nih.gov/pubmed/20008937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1863009
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