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Synthesis and biochemical evaluation of des-vinyl secologanin aglycones with alternate stereochemistry

Based on the X-ray structure of the enzyme strictosidine synthase, the glucose moiety of the seco-iridoid glucoside, secologanin, appears to be the key for orienting the substrate. We hypothesized that removing the glucose moiety would allow alternate stereoisomers of secologanin to be turned over....

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Библиографические подробности
Главные авторы: Bernhardt, Peter, O’Connor, Sarah E.
Формат: Artigo
Язык:Inglês
Опубликовано: 2009
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2799893/
https://ncbi.nlm.nih.gov/pubmed/20161519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2009.09.171
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