Error-prone translesion replication of damaged DNA suppresses skin carcinogenesis by controlling inflammatory hyperplasia

The induction of skin cancer involves both mutagenic and proliferative responses of the epidermis to ultraviolet (UV) light. It is believed that tumor initiation requires the mutagenic replication of damaged DNA by translesion synthesis (TLS) pathways. The mechanistic basis for the induction of prol...

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Main Authors: Tsaalbi-Shtylik, Anastasia, Verspuy, Johan W. A., Jansen, Jacob G., Rebel, Heggert, Carlée, Leone M., van der Valk, Martin A., Jonkers, Jos, de Gruijl, Frank R., de Wind, Niels
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2009
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2799833/
https://ncbi.nlm.nih.gov/pubmed/20007784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0909507106
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