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Temporal self-organization of the cyclin/Cdk network driving the mammalian cell cycle
We propose an integrated computational model for the network of cyclin-dependent kinases (Cdks) that controls the dynamics of the mammalian cell cycle. The model contains four Cdk modules regulated by reversible phosphorylation, Cdk inhibitors, and protein synthesis or degradation. Growth factors (G...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2799800/ https://ncbi.nlm.nih.gov/pubmed/20007375 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0903827106 |
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