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Mitaplatin, a potent fusion of cisplatin and the orphan drug dichloroacetate

The unique glycolytic metabolism of most solid tumors, known as the Warburg effect, is associated with resistance to apoptosis that enables cancer cells to survive. Dichloroacetate (DCA) is an anticancer agent that can reverse the Warburg effect by inhibiting a key enzyme in cancer cells, pyruvate d...

詳細記述

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書誌詳細
主要な著者: Dhar, Shanta, Lippard, Stephen J.
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2009
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2799774/
https://ncbi.nlm.nih.gov/pubmed/20007777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0912276106
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