Acute Administration of Non-Classical Estrogen Receptor Agonists Attenuates Ischemia-Induced Hippocampal Neuron Loss in Middle-Aged Female Rats

BACKGROUND: Pretreatment with 17β-estradiol (E2) is profoundly neuroprotective in young animals subjected to focal and global ischemia. However, whether E2 retains its neuroprotective efficacy in aging animals, especially when administered after brain insult, is largely unknown. METHODOLOGY/PRINCIPA...

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Autors principals: Lebesgue, Diane, Traub, Michael, De Butte-Smith, Maxine, Chen, Christopher, Zukin, R. Suzanne, Kelly, Martin J., Etgen, Anne M.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2010
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2799530/
https://ncbi.nlm.nih.gov/pubmed/20062809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0008642
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