Estradiol Attenuates Ischemia-Induced Death of Hippocampal Neurons and Enhances Synaptic Transmission in Aged, Long-Term Hormone-Deprived Female Rats

BACKGROUND: Transient global forebrain ischemia causes selective, delayed death of hippocampal CA1 pyramidal neurons, and the ovarian hormone 17β-estradiol (E2) reduces neuronal loss in young and middle-aged females. The neuroprotective efficacy of E2 after a prolonged period of hormone deprivation...

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Autores principales: Inagaki, Tomoko, Kaneko, Naoki, Zukin, R. Suzanne, Castillo, Pablo E., Etgen, Anne M.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2012
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3366987/
https://ncbi.nlm.nih.gov/pubmed/22675505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0038018
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