Phase 1 Safety and Immunogenicity Evaluation of ADVAX, a Multigenic, DNA-Based Clade C/B' HIV-1 Candidate Vaccine

BACKGROUND: We conducted a Phase I dose escalation trial of ADVAX, a DNA-based candidate HIV-1 vaccine expressing Clade C/B' env, gag, pol, nef, and tat genes. Sequences were derived from a prevalent circulating recombinant form in Yunnan, China, an area of high HIV-1 incidence. The objective w...

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Bibliographic Details
Main Authors: Vasan, Sandhya, Schlesinger, Sarah J., Huang, Yaoxing, Hurley, Arlene, Lombardo, Angela, Chen, Zhiwei, Than, Soe, Adesanya, Phumla, Bunce, Catherine, Boaz, Mark, Boyle, Rosanne, Sayeed, Eddy, Clark, Lorna, Dugin, Daniel, Schmidt, Claudia, Song, Yang, Seamons, Laura, Dally, Len, Ho, Martin, Smith, Carol, Markowitz, Martin, Cox, Josephine, Gill, Dilbinder K., Gilmour, Jill, Keefer, Michael C., Fast, Patricia, Ho, David D.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2010
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2799527/
https://ncbi.nlm.nih.gov/pubmed/20111582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0008617
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