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The Acid Test: The Discovery of Two Pore Channels (TPCs) as NAADP-Gated Endolysosomal Ca(2+) Release Channels

In this review we describe the background and implications of our recent discovery that Two pore channels (TPCs) comprise a novel class of calcium release channels gated by the intracellular messenger nicotinic acid adenine dinucleotide phosphate (NAADP). Their localization to the endolysosomal syst...

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Autors principals: Galione, Antony, Evans, A. Mark, Ma, Jianjie, Parrington, John, Arredouani, Abdelilah, Cheng, Xiaotong, Zhu, Michael X.
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2799329/
https://ncbi.nlm.nih.gov/pubmed/19475418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00424-009-0682-y
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