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Minimum energy path for a U6 RNA conformational change involving protonation, base pair rearrangement and base flipping
The U6 RNA internal stem-loop (U6 ISL) is a highly conserved domain of the spliceosome that is important for pre-mRNA splicing. The U6 ISL contains an internal loop that is in equilibrium between two conformations controlled by the protonation state of an adenine (pKa = 6.5). Lower pH favors formati...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2799254/ https://ncbi.nlm.nih.gov/pubmed/19591840 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2009.07.003 |
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