VDAC2 is required for truncated BID-induced mitochondrial apoptosis by recruiting BAK to the mitochondria

Truncated BID (tBID), a proapoptotic BCL2 family protein, induces BAK/BAX-dependent release of cytochrome c and other mitochondrial intermembrane proteins to the cytosol to induce apoptosis. The voltage-dependent anion channels (VDACs) are the primary gates for solutes across the outer mitochondrial...

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Hlavní autoři: Roy, Soumya Sinha, Ehrlich, Amy M, Craigen, William J, Hajnóczky, György
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2009
Témata:
Scientific Report
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2799216/
https://ncbi.nlm.nih.gov/pubmed/19820692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2009.219
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