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Tgif1 and Tgif2 regulate Nodal signaling and are required for gastrulation
Tgif1 and Tgif2 are transcriptional co-repressors that limit the response to TGFβ signaling and play a role in regulating retinoic-acid-mediated gene expression. Mutations in human TGIF1 are associated with holoprosencephaly, but it is unclear whether this is a result of deregulation of TGFβ/Nodal s...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Company of Biologists
2010
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2799159/ https://ncbi.nlm.nih.gov/pubmed/20040491 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.040782 |
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