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Tgif1 and Tgif2 regulate Nodal signaling and are required for gastrulation

Tgif1 and Tgif2 are transcriptional co-repressors that limit the response to TGFβ signaling and play a role in regulating retinoic-acid-mediated gene expression. Mutations in human TGIF1 are associated with holoprosencephaly, but it is unclear whether this is a result of deregulation of TGFβ/Nodal s...

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Detalhes bibliográficos
Main Authors: Powers, Shannon E., Taniguchi, Kenichiro, Yen, Weiwei, Melhuish, Tiffany A., Shen, Jun, Walsh, Christopher A., Sutherland, Ann E., Wotton, David
Formato: Artigo
Idioma:Inglês
Publicado em: Company of Biologists 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2799159/
https://ncbi.nlm.nih.gov/pubmed/20040491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.040782
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