A Novel Method to Adjust Efficacy Estimates for Uptake of Other Active Treatments in Long-Term Clinical Trials

BACKGROUND: When rates of uptake of other drugs differ between treatment arms in long-term trials, the true benefit or harm of the treatment may be underestimated. Methods to allow for such contamination have often been limited by failing to preserve the randomization comparisons. In the Fenofibrate...

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Main Authors:	Simes, John, Voysey, Merryn, O'Connell, Rachel, Glasziou, Paul, Best, James D., Scott, Russell, Pardy, Christopher, Byth, Karen, Sullivan, David R., Ehnholm, Christian, Keech, Anthony
Format:	Artigo
Sprog:	Inglês
Udgivet:	Public Library of Science 2010
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2798963/ https://ncbi.nlm.nih.gov/pubmed/20072614 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0008580
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A Novel Method to Adjust Efficacy Estimates for Uptake of Other Active Treatments in Long-Term Clinical Trials

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