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A Novel Method to Adjust Efficacy Estimates for Uptake of Other Active Treatments in Long-Term Clinical Trials

BACKGROUND: When rates of uptake of other drugs differ between treatment arms in long-term trials, the true benefit or harm of the treatment may be underestimated. Methods to allow for such contamination have often been limited by failing to preserve the randomization comparisons. In the Fenofibrate...

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Detalhes bibliográficos
Main Authors: Simes, John, Voysey, Merryn, O'Connell, Rachel, Glasziou, Paul, Best, James D., Scott, Russell, Pardy, Christopher, Byth, Karen, Sullivan, David R., Ehnholm, Christian, Keech, Anthony
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2798963/
https://ncbi.nlm.nih.gov/pubmed/20072614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0008580
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