Molecular Correlates of High-Level Antifolate Resistance in Rwandan Children with Plasmodium falciparum Malaria

Antifolate drugs have an important role in the treatment of malaria. Polymorphisms in the genes encoding the dihydrofolate reductase and dihydropteroate synthetase enzymes cause resistance to the antifol and sulfa drugs, respectively. Rwanda has the highest levels of antimalarial drug resistance in...

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Autori principali: Karema, Corine, Imwong, Mallika, Fanello, Caterina I., Stepniewska, Kasia, Uwimana, Aline, Nakeesathit, Supatchara, Dondorp, Arjen, Day, Nicholas P., White, Nicholas J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2010
Soggetti:
Mechanisms of Resistance
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2798539/
https://ncbi.nlm.nih.gov/pubmed/19841150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00498-09
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