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In Vitro Activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with Defined Macrolide Resistance Mechanisms

CEM-101 had MIC ranges of 0.002 to 0.016 μg/ml against macrolide-susceptible pneumococci and 0.004 to 1 μg/ml against macrolide-resistant phenotypes. Only 3 strains with erm(B), with or without mef(A), had CEM-101 MICs of 1 μg/ml, and 218/221 strains had CEM-101 MICs of ≤0.5 μg/ml. CEM-101 MICs were...

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Autors principals: McGhee, Pamela, Clark, Catherine, Kosowska-Shick, Klaudia M., Nagai, Kensuke, Dewasse, Bonifacio, Beachel, Linda, Appelbaum, Peter C.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2798494/
https://ncbi.nlm.nih.gov/pubmed/19884376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01123-09
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