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Cellular Pharmacology of the Anti-Hepatitis B Virus Agent β-l-2′,3′-Didehydro-2′,3′-Dideoxy-N(4)-Hydroxycytidine: Relevance for Activation in HepG2 Cells

ß-l-2′,3′-Didehydro-2′,3′-dideoxy-N(4)-hydroxycytidine (l-Hyd4C) was demonstrated to be an effective and highly selective inhibitor of hepatitis B virus (HBV) replication in HepG2.2.15 cells (50% effective dose [ED(50)] = 0.03 μM; 50% cytotoxic dose [CD(50)] = 2,500 μM). In the present study, we inv...

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Bibliografski detalji
Glavni autori: Matthes, E., Bünger, H.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2010
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2798482/
https://ncbi.nlm.nih.gov/pubmed/19917760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01176-09
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