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Differential Specificity and Immunogenicity of Adenovirus Type 5 Neutralizing Antibodies Elicited by Natural Infection or Immunization
A recent clinical trial of a T-cell-based AIDS vaccine delivered with recombinant adenovirus type 5 (rAd5) vectors showed no efficacy in lowering viral load and was associated with increased risk of human immunodeficiency virus type 1 (HIV-1) infection. Preexisting immunity to Ad5 in humans could th...
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主要な著者: | , , , , , , , , , , , , , |
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フォーマット: | Artigo |
言語: | Inglês |
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American Society for Microbiology (ASM)
2010
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オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2798414/ https://ncbi.nlm.nih.gov/pubmed/19846512 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00866-09 |
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