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Differential Specificity and Immunogenicity of Adenovirus Type 5 Neutralizing Antibodies Elicited by Natural Infection or Immunization

A recent clinical trial of a T-cell-based AIDS vaccine delivered with recombinant adenovirus type 5 (rAd5) vectors showed no efficacy in lowering viral load and was associated with increased risk of human immunodeficiency virus type 1 (HIV-1) infection. Preexisting immunity to Ad5 in humans could th...

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書誌詳細
主要な著者: Cheng, Cheng, Gall, Jason G. D., Nason, Martha, King, C. Richter, Koup, Richard A., Roederer, Mario, McElrath, M. Juliana, Morgan, Cecilia A., Churchyard, Gavin, Baden, Lindsey R., Duerr, Ann C., Keefer, Michael C., Graham, Barney S., Nabel, Gary J.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology (ASM) 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2798414/
https://ncbi.nlm.nih.gov/pubmed/19846512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00866-09
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