Differential Specificity and Immunogenicity of Adenovirus Type 5 Neutralizing Antibodies Elicited by Natural Infection or Immunization

A recent clinical trial of a T-cell-based AIDS vaccine delivered with recombinant adenovirus type 5 (rAd5) vectors showed no efficacy in lowering viral load and was associated with increased risk of human immunodeficiency virus type 1 (HIV-1) infection. Preexisting immunity to Ad5 in humans could th...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Cheng, Cheng, Gall, Jason G. D., Nason, Martha, King, C. Richter, Koup, Richard A., Roederer, Mario, McElrath, M. Juliana, Morgan, Cecilia A., Churchyard, Gavin, Baden, Lindsey R., Duerr, Ann C., Keefer, Michael C., Graham, Barney S., Nabel, Gary J.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society for Microbiology (ASM) 2010
Θέματα:
Vaccines and Antiviral Agents
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2798414/
https://ncbi.nlm.nih.gov/pubmed/19846512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00866-09
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