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Ebolavirus VP24 Binding to Karyopherins Is Required for Inhibition of Interferon Signaling
The Ebolavirus VP24 protein counteracts alpha/beta interferon (IFN-α/β) and IFN-γ signaling by blocking the nuclear accumulation of tyrosine-phosphorylated STAT1 (PY-STAT1). According to the proposed model, VP24 binding to members of the NPI-1 subfamily of karyopherin alpha (KPNα) nuclear localizati...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Microbiology (ASM)
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2798383/ https://ncbi.nlm.nih.gov/pubmed/19889762 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01372-09 |
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